“Quoad vitam” prognosis of CDLS person is not clearly reduced. They are in fact well known patients who are in the young adult age.

The possible presence of severe major malformations influence deeply the prognosis.

Heart malformations and diaphragmatic hernia are in fact the most important causes of death in the first years of life.

Other causes are related to a late or to a missed diagnosis of a medical complication of the syndrome (intestinal occlusion secondary to intestinal volvolus, aspiration pneumonia in patient with severe gastro-esophageal reflux).